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NAC supplementation (600 mg/day) has been shown to improve flow-mediated dilation in patients with chronic heart failure in a small RCT (Andrews et al., J Am Coll Cardiol, 2001) [65]

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The PubMed and Google Scholar databases were searched manually using the following keywords: N-Acetylcysteine, PCOS, Oxidative stress, Antioxidants, and Infertility alone and/or in combination to find studies relevant to the topic of research

The 2026 broader peptide-therapy reviews (PMID 41966639) place this compound class in the wider research-context of unapproved compounds under active investigation